Dihydroergotamine Mesylate( (+)-Dihydroergotamine )

Catalog No. M15343 CAS No. 6190-39-2

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Datasheet

HNMR

HPLC

MSDS

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Product Name

Dihydroergotamine Mesylate
Note

Research use only, not for human use.
Brief Description

Dihydroergotamine mesylate is an ergot alkaloid used to treat migraines.
Description

Dihydroergotamine mesylate is an ergot alkaloid used to treat migraines.
In Vitro

——
In Vivo

Animal Model:HepG2 cell xenografted mice Dosage:44 mg/kg plus 30 mg/kg of Sorafenib Administration:oral gavage,a total of 31 days of treatment, a gavage every day for 5 days in a row, followed by 2 days of rest. Result:Reduced the average tumor weight and tumor volumes in the combined therapy group compared with either compound alone or control group. Reduced Ki67 positive cells, reduced expression of Mcl-1, p-Mcl-1 and p-ERK.
Synonyms

(+)-Dihydroergotamine
Pathway

Endocrinology/Hormones
Target

5-HT Receptor
Recptor

5-HT
Research Area

Neurological Disease
Indication

——

CAS Number

6190-39-2
Formula Weight

679.8
Molecular Formula

C34H41N5O8S
Purity

>98% (HPLC)
Solubility

DMSO: 100 mM
SMILES

O=C([C@@H](CN(C)[C@]1([H])C2)C[C@]1([H])C3=C4C2=CNC4=CC=C3)N[C@](C(N5[C@H]6CC7=CC=CC=C7)=O)(C)O[C@@]5(O)[C@]8([H])CCCN8C6=O.OS(=O)(C)=O
Chemical Name

(2R,4R,7R)-N-[(1S,2S,4R,7S)-7-Benzyl-2-hydroxy-4-methyl-5,8-dioxo-3-oxa-6,9-diazatricyclo[7.3.0.02,6]dodecan-4-yl]-6-methyl-6,11-diazatetracyclo-[7.6.1.02,7.012,16]hexadeca-1(16),9,12,14-tetraene-4-carboxamide mesylate

1. Colman I, et al. Ann Emerg Med, 2005. 45(4): p. 393-40

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